Lathyrism Totally Explained

Everything about Lathyrism totally explained

Lathyrism or Neurolathyrism is a neurological disease of humans and domestic animals, caused by eating certain legumes of the genus Lathyrus. This problem is mainly associated with Lathyrus sativus (also known as Grass pea, Khesari Dhal or Almorta) and to a lesser degree with Lathyrus cicera, Lathyrus ochrus and Lathyrus clymenum. The lathyrism resulting from the ingestion of Lathyrus odoratus seeds (Sweet peas) is often referred to as odoratism, which is caused by a different toxin (Beta-amino-propionitrile) and affects the linking of collagen, a protein of connective tissues.

Symptoms

The consumption of large quantities of Lathyrus grain containing high concentrates of the neurotoxin beta-oxalyl-L-alpha,beta-diaminopropionic acid (or ODAP) causes paralysis, characterized by lack of strength in or inability to move the lower limbs. The poison responsible in the peas is the glutamate analogue beta-(N)-oxalylamino-L-alanine acid (BOAA), also known as beta-N-oxalyl-diamino-propionic acid (beta-ODAP). Unique symptom of Lathyrism is emaciation of Gluteal muscles (Buttocks). ODAP is a Poison of mitochondria, leading to excess cell death, especially motor neurons. Further reading in Homeopathy Lathyrus sativus.

Prevalence

This disease is prevalent in some areas of Bangladesh, Ethiopia, India and Nepal, and affects more men than women. The reason for this is unclear, female hormones have been suggested to offer a measure of protection, but also less food allocation and less oxidatively stressful activity [work] are plausible.

Causes

The toxicological cause of the disease has been attributed to the neurotoxin beta-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP) which acts as a structural analogue of the neurotransmitter glutamate. Ingestion of legumes containing the toxin results mostly from ignorance of their toxicity and usually occurs where the despair of poverty and malnutrition leaves little other food options. can also be caused by food adulteration.
Notice: The structure shown here (Oxalyldiaminopropionic acid) is alpha-N-oxalyl-L-alpha,beta-diaminopropionic acid, but not beta-N-oxalyl-L-alpha,beta-diaminopropionic acid

Prevention

Recent research suggests that sulfur amino acids have a protective effect against the toxicity of ODAP.
Food preparation is also an important factor. Toxic amino acids are readily soluble in water and can be leached. Bacterial (lactic acid) and fungal (tempeh) fermentation is useful to reduce ODAP content. Moist heat (boiling, steaming) denatures proteinase inhibitors which otherwise add to the toxic effect of raw grasspea through depletion of protective sulfur amino acids.
The underlying cause for excessive consumption of grasspea is a lack of alternative food sources. This is a consequence of poverty and political conflict. The prevention of lathyrism is therefore a socio-economic challenge.

Historical occurrence

The first mentioned intoxication goes back to ancient India and also Hippocrates mentiones a neurological disorder 46 B.C. in Greece caused by Lathyrus seed. Lathyrism was occurring in regular basis.
During the Spain War of Independence against Napoleon, grasspea served as a famine food. This was the subject of one of Francisco de Goya's famous aquatint prints titled Gracias a la Almorta ("Thanks to the Grasspea"), depicting poor people surviving on a porridge made from grasspea flour, one of them lying on the floor, already crippled by it.
In the film 'Ashes' [Englishtitle] by Andrzej Wajda based on the novel Popioly [Polishtitle] translated as 'Lost army' [Englishtitle] by Stefan Zeromski spanning the period 1798-1812, a horse is poisoned by grain from a Spanish village. The footage of the horse losing control of its hindlegs suggests that it was fed with Almortas. The scene with the horse falling down a steep cliff is very graphic.

Modern occurrence

During the post-war period in Spain, there were several outbreaks of lathyrism, caused by the shortage of food, which led people to consume excessive amounts of Almorta flour.
In Spain, a seed mixture known as comuña consisting of Lathyrus sativus, L. cicera, Vicia sativa and V. ervilia provides a potent mixture of toxic amino acids to poison monogastric (single stomached) animals. Particularly the toxin beta-cyanoalanine from seeds of V. sativa enhances the toxicity of such a mixture through its inhibition of sulfur amino acid metabolism [conversionof methionine to cysteine leading to excretion of cystathionine in urine] and hence depletion of protective reduced thiols. Its use for sheep doesn't pose any lathyrism problems if doses don't exceed 50 percent of the ration.

Related conditions

A related disease has been identified and named Osteolathyrism, caused by the toxin beta-amino-propionitrile (BAPN) because it affects the bones and connecting tissues, instead the nervous system. It is a skeletal disorder characterized by hernias, dissecting aortic aneurysms, lameness of the hind legs, exostoses, and kyphoscoliosis and other skeletal deformities, apparently as the result of defective aging of collagen tissue. The cause of this disease is attributed to beta-aminopropionitrile (BAPN), which inhibits the copper-containing enzyme lysyl oxidase, responsible for cross-linking procollagen and proelastin. BAPN is also a metabolic product of a compound present in sprouts of grasspea, pea and lentils.

Further Information

Get more info on 'Lathyrism'.

External Link Exchanges

Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:

<a href="http://lathyrism.totallyexplained.com">Lathyrism Totally Explained</a>

Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned.